The organizational set-up of the Department consists of following various Divisions/Sections, namely:

(1) Establishments
(2) Planning, Evaluation &Co-ordination
(3) Budget & Expenditure
(4) Accounts
(5) General Administration
(6) Small Scale Industries
(7) Handlooms
(8) Handicrafts
(9) Food Processing Industries
(10) DIC Monitoring Cell
(11) Khadi & Village Industries
(12) Training Centres
(13) EDP
(14) Marketing
(15) Investments
(16) Trade & Commerce
(17) Geology & Mining
(18) Factory & Boilers
(19) Partnership Registration, etc.

In the Districts, there are 9 (nine) DICs, one in each of the 9 Districts, along with 2 (two) DIC Sub-Centres, one at Jiribam in Imphal East district and the other at Kangpokpi in Senapati district.

The most important activities of the Department are in the V&SE (Village & Small Enterprise) Sector.

The State Govt. pays due importance on the development of industry, minerals, & commerce (export-import) with the main objectives for generation of employment and bringing about economic development.